Wise County, Virginia is located in the Lenowisco Health District. It has 403.4 square miles of land area and is the 44th largest county in Virginia by total area. It is bordered by Dickenson, Lee, Norton City, Scott, and Russell County, Virginia, and Pike, Letcher, and Harlan County, Kentucky. There are 11 census tracts in the county. The county FIPS number is 51195.

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