Southampton County, Virginia is located in the Western Tidewater Health District. It has 599.2 square miles of land area and is the 10th largest county in Virginia by total area. It is bordered by Greensville, Franklin, Surry, Suffolk, Sussex and Isle of Wight Counties, Virginia, and Hertford, Gates, and Northampton County, North Carolina. There are 6 census tracts in the county. The county FIPS number is 51175.

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