Giles County, Virginia is located in the New River Health District. It has 357.2 square miles of land area and is the 53rd largest county in Virginia by total area. It is bordered by Montgomery, Bland, and Pulaski Counties, Virginia, and Summers, Mercer, and Monroe Counties, West Virginia. There are 4 census tracts in the county. The county FIPS number is 51071.

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